Motor Neurone Disease/ALS

  • Specialist clinical expertise
    • Defined patient cohorts
    • 70% of cases in state registered and phenotyped at single location
    • Collection of genetic and biological material
  • Rat/mouse models of MND (SOD-1 overexpression)
  • Cell-based models of highly characterised MN-like cell lines
  • Research Interest
  • Copper and zinc in MND/ALS
  • ER stress and cell transport in MND/ALS
  • PDI as a biomarker and therapeutic target