Motor Neurone Disease/ALS
- Specialist clinical expertise
- Defined patient cohorts
- 70% of cases in state registered and phenotyped at single location
- Collection of genetic and biological material
- Rat/mouse models of MND (SOD-1 overexpression)
- Cell-based models of highly characterised MN-like cell lines
- Research Interest
- Copper and zinc in MND/ALS
- ER stress and cell transport in MND/ALS
- PDI as a biomarker and therapeutic target